AAAR 30th Annual Conference
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Philip Demokritou

A novel technique for pulmonary and cardiovascular toxicological characterization of inhaled engineered nanomaterials

PHILIP DEMOKRITOU, Georgios A Sotiriou, Edgar Diaz, John Godleski, Joseph Brain, Sotiris E Pratsinis

Harvard University

     Abstract Number: 71
     Last modified: March 29, 2011

     Working Group: Health Related Aerosols

The current nanotoxicology approach of evaluating the toxic properties of the large universe of engineered nanomaterials (ENMs) one material at a time will place a significant financial burden on an emerging industry and may slow down its development significantly. Alternatively, a promising approach will be to examine families of ENMs, and to study the links between their properties and specific biological outcomes. The lack of reliable methods to generate industry-relevant and property-controlled, ENM exposure atmospheres suitable for animal inhalation studies makes it difficult for predictive nanotoxicology to evolve.

Here, a novel method which is suitable for ENM in-vivo inhalation toxicological characterization studies is presented . The ability of the technique to generate a variety of industry-relevant, property-controlled exposure atmospheres for inhalation studies was systematically investigated. The suitability of the technique to characterize the pulmonary and cardiovascular effects of inhaled ENMs in intact animal models was also demonstrated in a study using in-vivo chemiluminescence (IVCL). The IVCL technique was found to be a highly sensitive method for identifying pulmonary and cardiovascular responses to inhaled ENMs under relatively small doses and acute exposures. It was demonstrated that moderate acute exposures to inhaled nanostructured Fe2O3 can cause both pulmonary and cardiovascular effects.

The future use of this novel platform will help to assess the cardiovascular, pulmonary and other toxicological effects of inhaled ENMs and improve our understanding on our central hypothesis that physical and chemical characteristics of inhaled ENMs determine their bioavailability, redistribution, and toxicity in the lungs and elsewhere.

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