AAAR 32nd Annual Conference
September 30 - October 4, 2013
Oregon Convention Center
Portland, Oregon, USA
Abstract View
Photoassisted One-step Aerosol Fabrication of Zwitterionic Chitosan Nanoparticles
JEONG HOON BYEON, Jeffrey Roberts, Department of Chemistry, Purdue University
Abstract Number: 571 Working Group: Nanoparticles and Materials Synthesis
Abstract Zwitterionic chitosan nanoparticles (ZCNPs) were conveniently obtained by a one-step aerosol method, and their potential for the production of biocompatible materials was investigated. A low molecular weight chitosan was conjugated with a succinic anhydride to produce zwitterionic chitosan (ZC). Collison atomized ZC droplets were simultaneously UV irradiated and dried in a tube furnace as a one-step aerosol process to form particles. The zeta potential of the ZCNPs could be easily tuned from pH 4-9, and it was more reactive for UV irradiated cases. On the other hand, the ZCNPs showed a slightly higher cytotoxicity (~85% in cell viability) than that for chitosan nanoparticles (CNPs, ~88%), and the UV irradiation of ZCs further decreased (~83%) cellular viability. The present aerosol process was effective to modify the CNP properties in a facile manner, which can then be employed for a wide range of biomedical purposes.