AAAR 35th Annual Conference October 17 - October 21, 2016 Oregon Convention Center Portland, Oregon, USA
Abstract View
The Contribution of Organic Aerosol to the Reactive Oxygen Species Formation on Lung Lining Fluid Interface
LIJIE LI, Shinichi Enami, Michael Hoffmann, Agustin Colussi, California Institute of Technology
Abstract Number: 715 Working Group: Health Related Aerosols
Abstract Epidemiological studies consistently reveal the adverse impacts of airborne particulate matter (PM) on human health. Asthma and chronic obstructive pulmonary diseases are deemed to associate with the reactive oxygen species (ROS) generated in lung lining fluids (LLF) upon inhalation of PM and oxidant pollutants. Primary and secondary organic aerosols are determined as ROS by bulk liquid chemical assays involving dithiothreitol (DTT) and ascorbic acid (AA). However, the interactions of PM with LLF are multiphase processes. Interfacial reactions may proceed at different rates, mechanisms and therefore generate different products compared with those in bulk media. Our previous work has demonstrated that some chemical reactions at the air-water interface proceed 10$^3 to 10$^6 faster than in bulk water. Thus, it is important to investigate the oxidative potential of organic aerosol at interfaces. Furthermore, it is important to identify the key intermediate species that induce oxidative stress and adverse health effect
This work incorporates the technique of gas-beam modulation and pulsed ion-gating detection to the existing coupled reactor and ES-MS (Electrospray Mass Spectrometry) system to investigate the ROS formed on the respiratory surface. The contribution of aerosol components to oxidation stress on LLF is evaluated. The cross effect of different components on ROS formation is further investigated.