AAAR 36th Annual Conference October 16 - October 20, 2017 Raleigh Convention Center Raleigh, North Carolina, USA
Abstract View
Facilitating Real-Time Exposure Studies on Traffic Related Air Pollution
Keith Bein, Christopher Wallis, Yongjing Zhao, ANTHONY WEXLER, University of California Davis
Abstract Number: 584 Working Group: Aerosol Exposure
Abstract Toxicological studies continue to demonstrate causal relationship between exposures to traffic related air pollution (TRAP), including gases and particles, and various metrics of adverse pulmonary, cardiovascular and neurological health effects. The key challenge in these studies is replicating true human exposure in models that mimic human biology on accelerated time scales with sufficient resolution in physiological and/or behavioral response to demonstrate statistical significance. A core need is an exposure paradigm that addresses these issues in a robust and dependable manner. It is hypothesized that a roadway tunnel system provides a platform for acute and chronic exposure studies that maximizes toxicological response and minimizes bias by allowing for real-time exposure to concentrated ambient TRAP. The objective of this research is to design, construct and implement a core exposure and measurement facility above the eastbound bores of the Caldecott tunnel in California’s Bay Area. First results from the operational characterization of this facility will be presented, including full physical and chemical characterization of the exposure environments.