10th International Aerosol Conference September 2 - September 7, 2018 America's Center Convention Complex St. Louis, Missouri, USA
Abstract View
Differential Toxicities of Airborne Fine Particulate Matter from Various Sources: A New Health Index for Monitoring Health Effects
MINHAN PARK, Hungsoo Joo, Kwangyul Lee, Myoseon Jang, Sang Don Kim, Injeong Kim, Lucille Joanna Borlaza, Heung-Bin Lim, Han-Jae Shin, Kyu Hyuck Chung, Yoon-Hyeong Choi, Sun Gu Park, Min-Suk Bae, Ji Yi Lee, Hangyul Song, Eunbi Lee, Enrique Cosep, Wajih Ur Rehman, Daeun Kim, Kihong Park, GIST
Abstract Number: 424 Working Group: Aerosol Toxicology
Abstract Fine particulate matter (PM) in the ambient atmosphere are strongly associated with adverse health effects. However, it is unlikely that all fine particles are equally toxic in view of their different sizes and chemical components. In this study, toxicity and chemical composition of PM produced from distinct sources (combustions sources (diesel engine, gasoline engine, biomass burning, and coal burning) and non-combustion sources (road dust, sea spray aerosols, ammonium sulfate, and ammonium nitrate)) including secondary organic aerosols produced from toluene, 1,3,5-trimethylbenzene (TMB), isoprene, and α-pinene under natural sunlight were evaluated. Multiple biological and chemical responses (oxidative potential, cell viability, genotoxicity (mutagenicity and DNA damage), oxidative stress, and inflammatory response) of various source-specific aerosols were integrated to derive source-specific toxicity and inhalation dose scores. Diesel engine exhaust particles were found to be the most toxic among the tested aerosols. A new health index was derived based on the differential toxicities and sizes of local and regional PM2.5 sources as well as ambient concentrations of PM2.5, and this new health index was observed to be more strongly associated with COPD mortality than PM2.5 mass. The new health index can be potentially served as a useful indicator to estimate the adverse health effects caused by different fine particle types and provide practical management of PM beyond what can be achieved using PM mass which is the current regulation standard.