10th International Aerosol Conference September 2 - September 7, 2018 America's Center Convention Complex St. Louis, Missouri, USA
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Synthesis of Large-Pore Submicron Mesoporous Silica using Salt-Assisted Spray Pyrolysis Method for Controlled Release Drug Delivery
Masoom Shaban, Jalal Poostforooshan, Sarah Reiser, Michael Türk, ALFRED P. WEBER, TU Clausthal
Abstract Number: 772 Working Group: Aerosols in Medicine
Abstract Research on mesoporous materials for drug delivery purposes has attracted much attention due to their low cost, non-toxic nature, suitable and adjustable pore diameter, and high specific surface area. However, the irregular bulk morphology of the mesoporous materials obtained by traditional methods is not perfect for drug delivery system. Therefore, to overcome this disadvantage, one strategy is to synthesize submicron mesoporous silica (SMS) with spherical morphology. From a clinical point of view, spherical SMS is widely accepted as the useful drug delivery system, because it can be easily ingested or injected.
In this work, salt-assisted spray pyrolysis was used as a facile aerosol route to obtain large-pore spherical SMS using simple inorganic salts as pore templates and nanocolloidal SiO2 as building blocks. Significantly, this approach avoids the need for any calcination process and mesoporous particles with high-purity can be produced which is very important in biomedical applications.
The morphology and mesoporous structure of spherical SMS were easily controlled using adjusting salt-to-SiO2 mole ratio. The textural properties and the topology of the resulting materials were investigated by employing diverse characterization techniques such as scanning mobility particle sizer (SMPS), Micromeretics ASAP 2020, transmission electron microscopy (TEM), and scanning electron microscopy (SEM). Most importantly, porosity was not observed in the particles before exposure to the water, it can be concluded that salt is responsible to induce porosity in the structure. Moreover, wide-angle X-ray diffraction (XRD) and inductively coupled plasma (ICP) results confirmed that there is no residue of salt in the SMS after washing with water.
Then, spray-pyrolysis synthesized spherical SMS was used as a promising carrier for racemic ibuprofen as a poorly water-soluble drug. Ibuprofen is often prescribed to treat e.g. arthritis, fever, and pains, however, its dissolution rate and therewith bioavailability is limited. Therefore, ibuprofen was deposited onto resulting spherical SMS using a controlled particle deposition (CPD) process. This process is a suitable and innovative method for the preparation of dissolution enhancing solid dosage forms without using any additional auxiliary materials.
Finally, it was observed that the ibuprofen loaded-SMS carriers exhibited higher dissolution performances compared to the commercial MCM-41 and SBA-15 type mesoporous silica. Furthermore, the obtained results indicated that there is a direct relationship between specific surface area and obtained drug loading. The SMS carriers with a higher surface area and larger pore volume lead to a higher number of ibuprofen monolayers.