AAAR 33rd Annual Conference
October 20 - October 24, 2014
Rosen Shingle Creek
Orlando, Florida, USA
Abstract View
3D Label-Free Prostate Specific Antigen Immunosensor Based on Graphene-Gold Nanocomposites
HEE DONG JANG, Sun Kyung Kim, Hankwon Chang, Korea Institute of Geoscience and Mineral Resources
Abstract Number: 152 Working Group: Nanoparticles and Materials Synthesis
Abstract Highly sensitive and label-free detection of the prostate specific antigen (PSA) remains a challenge in the diagnosis of prostate cancer. Here, a novel three-dimensional (3D) electrochemical immunosensor capable of sensitive and label-free detection of PSA is reported. This unique immunosensor is equipped with a highly conductive graphene (GR)-based gold (Au) nanocomposite modified electrode. The GR-based Au nanocomposite is prepared using aerosol spray pyrolysis and the morphology of the nanocomposite is the shape of a crumpled GR ball decorated with Au nanoparticles. Unlike previous research, this novel 3D immunosensor functions very well over a broad linear range of 0-10 ng/mL with a low detection limit of 0.005 ng/ml; furthermore, it exhibits a significantly increased electron transfer and high sensitivity toward PSA. The highest rate of current change according to the PSA concentration is 49 µA. Satisfactory selectivity, reproducibility, and stability of the 3D immunosensor are also exhibited.