AAAR 33rd Annual Conference
October 20 - October 24, 2014
Rosen Shingle Creek
Orlando, Florida, USA
Abstract View
Bio-nanoparticles as Candidate Reference Materials for Mobility Analysis of Nanoparticles
RIAN YOU, Mingdong Li, Suvajyoti Guha, George Mulholland, Michael Zachariah, University of Maryland
Abstract Number: 294 Working Group: Instrumentation and Methods
Abstract We propose bio-nanoparticles as a candidate reference material for determining the mobility of nanoparticles over the range of 6×10$^(-8) m$^2/V·s to 5×10$^(-6) m$^2/V·s . Using an electro-spray differential mobility analyzer (ES-DMA), we measured the empirical distribution of several biomaterials. All of them show monomodal distributions that are more than two times narrower than the currently used calibration particles for mobility larger than 6×10$^(-8) m$^2/V·s (diameters less than 60 nm). We also present a numerical method to calculate corrected distributions of bio-nanoparticles by separating the contribution of the diffusive transfer function. The corrected distribution is about 20 % narrower than the empirical distributions. Even with the correction, the reduced width of the mobility distribution is about a factor of two larger than the diffusive transfer function. The additional broadening could result from the non-uniform conformation of biomaterials and from the presence of volatile impurities or solvent adducts. The mobilities of these investigated biomaterials are stable over a range of buffer concentration and molarity, with no evidence of temporal degradation over several weeks.