AAAR 36th Annual Conference October 16 - October 20, 2017 Raleigh Convention Center Raleigh, North Carolina, USA
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Bioaccessibility and Health Risk of Trace Elements in Fine Particulate Matter Using Different Simulated Body Fluids
DONGYANG NIE, Mindong Chen, Xinlei Ge, Yun Wu, Nanjing University of Information Science & Technology
Abstract Number: 702 Working Group: Health Related Aerosols
Abstract Long-term exposure PM2.5-bound metal have been proved to cause hazardous effects to human health. In this study, the bioaccessibility and health risk of trace elements in fine particulate matter were investigated. Four kinds of simulated body fluids were employed to extract the PM2.5 for simulating different exposure routes (inhalation, ingestion and dermal contact). Phosphate buffered saline(PBS) and the artificial lysosomal fluid (ALF) were used as surrogate human lung fluids, artificial sweat(AS) was used for simulating dermal contract, artificial gastric juice was employed to mimic human digestion. It showed that many trace elements were less soluble in PBS than other body fluid, especially for Pb Al. Cu, Mn, V, As were observed to be the most soluble trace elements in all simulated body fluids. The United States Environmental Protection Agency (USEPA) human health risk assessment model was used to assess the carcinogenic and non-carcinogenic effects. The results showed the carcinogenic risks from As, Cr, and Pb were higher than 10-6(an acceptable level for human health) especially for children, indicating that there were potential carcinogenic risks posed by these toxic elements. The high hazard quotient value for As, Cr, and Pb were also observed to children. It suggested that the sampling site was experiencing trace elements pollution, especially for As, Cr, and Pb.