10th International Aerosol Conference September 2 - September 7, 2018 America's Center Convention Complex St. Louis, Missouri, USA
Abstract View
Development and Evaluation of Dry Powder Aerosol Generator with Nozzle and Magnetic Stirrer for Inhalation Toxicity Testing of Nanomaterials
GUN-HO LEE, Kang-Ho Ahn, Hanyang University, R. of Korea
Abstract Number: 1128 Working Group: Instrumentation
Abstract Recently, with the rapid development of nanotechnology, many nanomaterials are being produced. These nanomaterials have unique characteristics that are quite different from those in the lump form and are widely used in many industrial fields. However, these nanomaterials may enter the body through the respiratory tract and cause pulmonary fibrosis in the lungs or may precipitate in the alveoli causing inflammation, which may be transferred to other organs through the blood vessels in the lungs, leading to secondary toxicity. As a result, the current risk assessment of nanomaterials is becoming a global issue. In order to perform inhalation toxicity testing, one of the methods for evaluating the risk of nanomaterials, an aerosol generator is important. It can make aerosol which can be inhaled by laboratory animals.
In this study, we developed a dry powder aerosol generator for inhalation toxicity testing of nanomaterials. The developed dry powder aerosol generator was evaluated for the factors that could affect the aerosol generation, mock inhalation toxicity testing verified that performance of aerosol generation is satisfied with recommendations of OECD test guideline. Finally, the short-term / sub-chronic inhalation toxicity testing of CNF was performed using a dry powder aerosol generator to verify the performance of an aerosol generator for inhalation toxicity testing of nanomaterials. Finally, short-term/ sub-chronic inhalation toxicity testing of CNF was performed using a dry powder aerosol generator and the performance as an aerosol generator for inhalation toxicity testing of nanomaterials was verified. The dry powder aerosol generator developed in this study is expected to contribute to the study of inhalation toxicity study of nanomaterials.