10th International Aerosol Conference September 2 - September 7, 2018 America's Center Convention Complex St. Louis, Missouri, USA
Abstract View
Method for the Production of "Universal" Inhalation Powders for Dry Powder Inhalers
Janne Raula, DAVID BROWN, Esko Kauppinen, Teicos Pharma
Abstract Number: 1164 Working Group: Aerosols in Medicine
Abstract Teicos Pharma has developed a unique inhalation drug formulation technology (trade named "Particle Stream Technology") which allows the production of highly flowable and dispersible inhalation powders (trade named "ProFlow Powder") from virtually any pharmaceutical agent and at low cost. This technology enables the production of highly efficient and fast acting inhalable "carrier free" formulations of wide range of active pharmaceutical ingredients (APIs), be they water soluable or insoluable, for pulmonary or systemic disease. The formulation also provides patients a painless and effective dosing procedure which avoids the side effects of traditional carrier containing inhalation formulations.
Carrier free formulations have been demonstrated to have a up to 99% API, compared to 1-2% API in traditional milled powders, Fine Particle Fractions (FPFs) above 55% compared to 10-15% in traditional milled powders and emitted doses of over 20x traditional milled formulations. In combination formulations including lactose carrier particles, we have achieved FPFs of greater than 90%. Emited doses have been demonstrated to be virtually independent of inhalation flow rate in the normal human inhalation range of 22 to 55 LPM. In-vitro tests have demonstrated safe biocompatablity.