10th International Aerosol Conference September 2 - September 7, 2018 America's Center Convention Complex St. Louis, Missouri, USA
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Secondhand Smoke Exposure during the Travel between United States and China: The Association with Urinary Biomarkers of Polycyclic Aromatic Hydrocarbons and Lipid Peroxidation
Yan Lin, Xinghua Qiu, YIFANG ZHU, University of California Los Angeles
Abstract Number: 266 Working Group: Aerosol Exposure
Abstract Secondhand smoke (SHS) was among top risk factors to general population. Exposure to SHS might vary among countries due to different smoking prevalence and control policies, but it is unclear whether cross-border traveling would bring significant health risk from SHS exposure to international travelers. In this study, we followed 27 non-smokers traveling between Los Angeles and Beijing. Their urine samples (n=196) were collected before (LA1), during (BJ), and after (LA2) the trip for the measurement of biomarkers of SHS (i.e. cotinine), polycyclic aromatic hydrocarbons (PAHs) and lipid peroxidation (i.e. malondialdehyde and 8-isoprostane). The geometric mean concentration of urinary cotinine was 0.13, 1.50, and 0.22 µg/g creatinine in LA1, BJ and LA2, respectively. Likewise, hydroxylated-PAHs (OH-PAHs) were also significantly higher in BJ than LA1 or LA2 (p<0.05). The increase of urinary OH-PAHs in BJ was partially attributed to SHS exposure given its significant association with urinary cotinine (p<0.05). Urinary cotinine was positively associated with malondialdehyde and 8-isoprostane (p<0.05). These results indicated an increase of SHS exposure caused by the travel from Los Angeles to Beijing, which might further contribute to an increase in PAHs exposure and lipid peroxidation.