10th International Aerosol Conference September 2 - September 7, 2018 America's Center Convention Complex St. Louis, Missouri, USA
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Aerosol Based Nanoscale Material Synthesis, Surface Engineering and Delivery to the Brain
RAMESH RALIYA, Nathan Reed, Debajit Saha, Dezhuang Ye, Tandeep Chadha, Hong Chen, Barani Raman, Pratim Biswas, Washington University in St. Louis
Abstract Number: 385 Working Group: Aerosols in Medicine
Abstract The brain is shielded by a group of parenchyma cells connected by tight junctions to protect the organ from foreign substances. The protecting layer of these cells, known as blood-brain barrier (BBB), creates an obstacle to the delivery and translocation of drugs to the brain. Current practices such as invasive delivery or non-invasive nasal droplet are limited either by a high risk of brain damage or slow and low volume delivery. In this study, we investigate a non-invasive approach, generating an aerosol suspension of ultra-small particles that can be delivered to the brain relatively faster than current medical practices. We used aerosol atomizers such as electrospray and Collison nebulizers to generate particles in the size range between 5 and 150 nm while maintaining particle properties and its uniform size distribution. The real-time particle size was measured by scanning mobility particle sizers. We have successfully tested the delivery of 5 nm gold particles to the locust brain and quantified particle delivery/uptake in the brain using inductively coupled plasma-mass spectroscopy. Building on this work, focused ultrasound technology is used for enhanced targeted delivery of nanoscale materials in the brain, potentially for brain cancer treatment. Such particles can be used as drug delivery vehicles, however, this would require a detailed investigation into the transport and delivery mechanism.