10th International Aerosol Conference September 2 - September 7, 2018 America's Center Convention Complex St. Louis, Missouri, USA
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Attachment Behavior and Aggregation Kinetics of Aerosol Synthesized Oxide Nanomaterials in Water
RAMESH RALIYA, Nathan Reed, Kwon Paul, Tiana Stussie, Patchaya Tobarameekul, Deep Hathi, Patcharin Worathanakul, Samuel Achilefu, Monica Shokeen, Pratim Biswas, Washington University in St. Louis
Abstract Number: 567 Working Group: Materials Synthesis
Abstract Oxide nanomaterials such as TiO2, Fe2O3, SiO2 and ZnO are manufactured at industrial scale for various applications such as paint, food and cosmetics. Recently, these nanomaterials are being explored for advanced biomedical applications including but not limited to cancer therapeutics, deep-tissue imaging and drug delivery. However, at nanoscale (between 1 and 100 nm at least at one dimension) these particles tend to agglomerate/aggregate very rapidly in the biologically compatible or FDA approved solvents for drug formulation. Because of the aggregation/agglomeration, it is very hard to harness the desired potential of the surface area to volume size phenomenon at the nanoscalea,b. In the present study, we investigate mechanistic of oxide nanomaterials aggregation or agglomeration behavior and elucidate the relationship between water chemistry and nanoparticle surface. We compared TiO2, Fe2O3, SiO2 and ZnO nanoparticles synthesized from two different methods, namely- flame/furnace aerosol and sol-gel. Particle stability and aggregation behavior were studied using time-resolved – dynamic light scattering (TR-DLS), and electron microscopy. Surface chemistry of the nanoparticles was characterized by electron microscopy and photon correlation spectroscopy. The data obtained from TR-DLS were used to calculate attachment efficiency of two particles. In summary, the study mechanistically reveals the particles behavior in the solvent and offer solvents conditions (pH, Ionic strength, zeta potential, concentration and physical force) to keep the oxide particles in their monodisperse state independent of the synthesis procedure.
a) Jiang, J., Oberdorster, G., Elder, A., Gelein, R., Mercer, P., and Biswas, P.: "Does nanoparticle activity depend upon size and crystal phase?", Nanotoxicology, 2, 33-42, 2008. b) Jiang, J. K., Oberdorster, G., and Biswas, P.: "Characterization of size, surface charge, and agglomeration state of nanoparticle dispersions for toxicological studies", Journal of Nanoparticle Research, 11, 77-89, 2009.