Global and Regional Simulations of EPFR Concentrations and ROS Formation in Lung Lining Fluid

MEREDITH SCHERVISH, Regina Luu, Simon Rosanka, Pascale Lakey, Annmarie Carlton, Manabu Shiraiwa, University of California, Irvine

     Abstract Number: 348
     Working Group: Aerosol Chemistry

Abstract
Environmentally persistent free radicals (EPFRs) in PM have received growing attention for their potential toxicity as they are redox active to form reactive oxygen species (ROS). EPFRs are formed from incomplete combustion, including biomass burning and vehicle exhaust. Their long atmospheric lifetime implies that, in addition to their main local sources, long-range transport may impact local concentrations of EPFRs. Measurements of EPFRs in PM have been conducted across the globe with concentrations ranging from 10¹⁶-10²⁰ spins/g of PM and have been shown to vary with different emissions sources as well as meteorological conditions. In this work, we estimate EPFR concentrations across the globe from GEOS-Chem and in the Southern California region using CMAQ. We utilize tight correlations between emission markers of biomass burning and vehicles and EPFR content in particulate matter. EPFR, iron, copper, and PM2.5 concentrations are then used as inputs to the KM-SUB-ELF model in order to predict the concentrations and production rates of ROS in the epithelial lining fluid (ELF).