Crumpled Graphene Oxide (CGO)-Based Drug Delivery System
YIMING XI, Shalinee Kavadiya, Daniel Bilbao, Russo Marco, Pratim Biswas, University of Miami
Abstract Number: 235
Working Group: Nanoparticles and Materials Synthesis
Abstract
Various methodologies continue to be developed for the treatment of cancer, with emphasis on improved specificity and targeted delivery to tumor cells. A crumpled graphene oxide (CGO)-based drug delivery system (DDS) for cancer treatment was synthesized via an aerosol approach to achieve enhanced drug loading capacity with an anti-cancer drug doxorubicin (DOX). The proposed system with reduced particle size and preserved surface modifiability for active tumor targeting was compared to current graphene oxide (GO)-based systems. The particle size, the drug loading capacity, the drug release profile, and the in vivo toxicity of the synthesized DDS nanoparticles were evaluated in the study.
The synthesis method for the CGO was a one-step aerosolized approach using a Furnace Aerosol Reactor (FuAR). The sheet, two-dimensional (2D) graphene oxide (GO) was aerosolized into droplets and passed through a heated tube furnace to evaporate the solvents. During the solvent evaporation, the sheet 2D GO was crumpled into three-dimensional (3D) structures, CGO, due to the capillary force compression [1]. From the study, the synthesized CGO had a surface area of 79.091, that was 8.6 times larger than the sheet graphene oxide 9.178, because the crumpling had minimized pi-pi interaction-induced stacking of GO. The crumpled graphene oxide exhibited similar drug loading capacity (0.52 ± 0.01 mg / mg) compared to GO (0.57 ± 0.07 mg /mg) and less drug released (11.23%) compared to GO (13.12%). In-vivo studies on mice indicated that the CGO demonstrated less toxicity (60 mg/kg) on mice than GO (7.5 mg/kg). The poster will further demonstrate additional data which will further provide improved understanding of the one-step aerosol-based synthesis for nanomaterials with applications in healthcare.
Key Words: Aerosol Synthesis; Crumpling; Drug Delivery; Graphene Oxide.
References:
[1] Wang, W.-N., Y. Jiang, and P. Biswas, Evaporation-induced crumpling of graphene oxide nanosheets in aerosolized droplets: confinement force relationship. The journal of physical chemistry letters, 2012. 3(21): p. 3228-3233.