AAAR 35th Annual Conference October 17 - October 21, 2016 Oregon Convention Center Portland, Oregon, USA
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What Factors Influence Electronic Cigarette Nicotine Yield and Delivery?
THOMAS EISSENBERG, Virginia Commonwealth University
Abstract Number: 3 Working Group: Electronic Cigarettes - Particle Generation
Abstract Electronic cigarettes (ECIGs) are a class of products that use a heating element to aerosolize for user inhalation a solution made of solvents like propylene glycol and/or vegetable glycerin, flavorants, and, usually, the stimulant drug nicotine. Nicotine yield is the amount (in milligrams) of nicotine contained in the aerosol that is emitted by the device. Nicotine delivery is the concentration (in nanograms/milliliter) of nicotine found in user blood plasma after ECIG use. Nicotine yield and delivery are influenced by a variety of factors including device power (battery voltage, heater resistance), liquid nicotine concentration, and user behavior. Data demonstrating the influence of these factors on ECIG nicotine yield and delivery will be presented. In addition, the presentation will include a discussion of the variability of nicotine delivery profiles of ECIG products on the US market, some of which delivery very little nicotine while others exceed the nicotine delivery profile of a tobacco cigarette under similar use conditions. These data are relevant to public health today, given the dramatic rise of ECIG use, particularly in populations where nicotine administration may have long-term adverse health outcomes (e.g., adolescents).