AAAR 35th Annual Conference October 17 - October 21, 2016 Oregon Convention Center Portland, Oregon, USA
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Toxicant Production in the Electronic Cigarette Reaction Vessel
ROBERT STRONGIN, David Peyton, James F. Pankow, Robert Jensen, Wentai Luo, Jorge Escobedo, Anna Duell, James Salamanca, Portland State University
Abstract Number: 474 Working Group: Electronic Cigarettes - Formulation
Abstract Knowledge of the mechanism of formation, levels and toxicological profiles of the chemical products in the aerosols of e-cigarettes is needed in order to better inform basic research as well as the general public, regulators and industry. To date, studies of e-cigarette emissions have mainly focused on chromatographic techniques for quantifying and comparing the levels of selected e-cigarette aerosol components to those found in traditional cigarettes. E-cigarettes heat and vaporize the solvents propylene glycol (PG) and glycerol (GLY), thereby affording unique product profiles as compared to traditional cigarettes. The chemical literature strongly suggest that there should be more compounds produced by PG and GLY than have been reported in e-cigarette aerosols to date. We previously reported the discovery of hemiacetal products of the reaction of PG/GLY with the formaldehyde that is formed during PG/GLY aerosol generation. Herein, we present a more extensive investigation of the products derived from vaporizing PG and GL Y under e-cigarette conditions. In addition to known e-cigarette PG/GLY derived products, many compounds have been identified for the first time under vaping conditions. Their origin and potential toxicological effects will be described.