AAAR 35th Annual Conference October 17 - October 21, 2016 Oregon Convention Center Portland, Oregon, USA
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Investigation of Health Effects of Beijing's Air Using a Mouse Model
XIANGYU ZHANG, Maosheng Yao, Peking University
Abstract Number: 499 Working Group: Health Related Aerosols
Abstract In recent decades, China is experiencing frequent haze events especially during the winter seasons. However, its adverse health effects are still not clearly elucidated. Here, we used mice as experimental models which were exposed to different dose of PM2.5 collected from Beijing during clear and haze days via injection. Blood samples were collected before injection and 1h, 2 days, 4 days, 6 days, 8 days after injection respectively. Five different biomarkers indicating oxidative damage and inflammatory responses were studied. Five main organs (heart, liver, spleen, lung and kidney) were also taken after euthanizing the rats, for anatomy and histopathological analysis. Simultaneously, we also recoded all behaviors of those control and exposed mice. The results showed that after 1h of PM2.5 injection, the levels of interleukin-6, C-reactive protein and endotoxin increased significantly compared to the control. In addition, our video recordings of those exposed mice with high PM2.5 loadings had a slow response to external interruption. PM2.5 collected from the haze days were shown to be more harmful than those collected from clear days.